Prof. Sudha Srivastava

BIOGRAPHY

Dr. Sudha Srivastava, Professor, joined JIIT in 2004. Before joining JIIT, she was a consultant at Indira Gandhi National Open University (IGNOU) Delhi for the planning and development of Post Graduate Diploma Program in Bioinformatics. She did her post doctoral training in molecular biology from All India Institute of Medical Sciences (AIIMS) with an independent DBT-Post Doctoral Fellowship(2002). At AIIMS she worked on structural analysis of domains of the non-structural proteins of Hepatitis E Virus.

She is an interdisciplinary person with Ph.D in Physical Sciences from Jawaharlal Nehru Universtiy(JNU), New Delhi (2002). She did her M.Phil., Msc(Hons) and B.Sc (Hons) in physical chemistry from Panjab University Chandigarh (1988-1995). She received fellowships from Jawaharlal Nehru Memorial Fund Fellowship for Research (2000), CSIR-UGC NET & Junior Research Fellowship(1995) and GATE (1994).

RESEARCH HIGHLIGHTS

Research interest of her group is in biomedical application of nanotechnology.  Currently, the research focus is on diagnostic device development for thyroid, cancer, pathogens etc. Use of nanotechnology for the development of biosensors with improved stability, sensitivity and response time is USP of our research group. Also working on nanoparticles based vaccine development. 

Her group’s expertise is in synthesis of metallic nanomaterials (gold, silver, copper), graphene, core shell nanoparticles, composite nanomaterials, polymeric nanoparticles etc. They have developed a biosensor for thyroid disease diagnosis and a  novel method for making nanoparticles of enzymes itself to enhance their thermal and pH stability.  

She is Technology Advisor for biosensor development  for Ecozyme AB, Lund, Sweden.

Technology Transfer

 

• Technology transfer to Thyrolytics AB, Sweden of the Indian Patent Application No 201811012008 “An improved electrode for electrochemical device”

PATENT(s)

Granted :

• Developed a process to make thermally stable enzyme nanoparticles (Indian Patent No 309474) S. Srivastava and S. Sharma
• Biosensor for Male Infertility (European Patent 3768825) K. Punyani, S. Srivastava, M. Takwa
• Biosensor for Diagnosis of Thyroid Dysfunction (European Patent 3775180) S. Srivastava, K. Punyani, M. Takwa

Filed :

• Sudha Srivastava and Rahul Saxena, “ An improved electrode for electrochemical device”  Indian Patent Application No 201811012008.
• Sudha Srivastava and Rahul Saxena, PCT application : Sudha Srivastava and Rahul Saxena, “ An improved electrode for electrochemical device”  PCT/IB2019/052388  25 March 2019

INDUSTRY PROJECT

• Biosensor Development - for Ecozyme AB, Lund, Sweden. (2018)
• Development of nano bio-fertilizer to supplement for N,P,K, Kanpur Fertilizer and Chemicals Limited, India (2023)

SPONSORED R & D PROJECT(S)

• “Development and evaluation of rapid diagnostic test/device for pediatric pulmonary tuberculosis based on the detection of host/mycobacterial proteins in urine sample” Co-PI :  Dr. Sudha Srivastava ICMR, Govt of India” (2024-2027)
•  “Development of Electrochemical biosensor for detection of circulating tumor DNA mutations in Acute myeloid leukemia”   PI :  Dr. Sudha Srivastava ICMR, Govt of India”(2022-2025)
• Application of customized PGPM based formulations for reclamation of soil permeated with Organophosphate pesticide residues. Co-I : Dr. Sudha Srivastava DBT, Govt of India (2017-2019)
• Nanoparticles based amperometric biosensors for detection of thyroid dysfunctioning, PI : Dr. Sudha Srivastava, DST, Govt of India (2014-2017).
• Designing a nanoparticle based glucose biosensor. PI: Dr. Sudha Srivastava, All India Council for Technical Education (AICTE) (2009-12)

PUBLICATIONS   

• Shilpa Gundagatti and Sudha Srivastava  An optimization of blocking agents for designing reliable electrochemical biosensors for ovarian cancer, Materials Today: Proceedings 2023, ISSN 2214-7853, https://doi.org/10.1016/j.matpr.2023.04.460.
• Namita Sharma and Sudha Srivastava miRNA 143 based nanobiosensor to diagnose pancreatic cancer, Materials Today: Proceedings, 2023, ISSN 2214-7853 https://doi.org/10.1016/j.matpr.2023.04.461
• Sharma N. and Srivastava S. Diagnosis of Pancreatic Cancer Using miRNA30e Biosensor Interdisciplinary Sciences: Computational Life Sciences (2022) 14(4), 804-813 /doi.org/10.1007/s12539-022-00531-1 [Impact factor: 3.49, Indexed in Scopus]
• Gundagatti S. and Srivastava S. Development of Electrochemical Biosensor for miR-204 Based Cancer Diagnosis Interdisciplinary Sciences - Computational Life Sciences,(2022) 14(2), 596-606. doi: 10.1007/s12539-022-00508-0 [Impact factor: 3.49, Indexed in Scopus]
• Rani, D., Nayak, B. and Srivastava, S. Smaller Sized Hepatitis E Virus ORF2 Protein-Chitosan Nanoemulsion Conjugate Elicits Improved Immune Response Biointerface Research in applied Chemistry (2023) 13(1), 2023, 46 https://doi.org/10.33263/BRIAC131.046 [Indexed in Scopus]
• Rani, D., Nayak, B. & Srivastava, S. Immunogenicity of gold nanoparticle-based truncated ORF2 vaccine in mice against Hepatitis E virus. 3 Biotech 11, 49 (2021). https://doi.org/10.1007/s13205-020-02573-y[Impact factor: 2.8, Indexed in Scopus]
• D. Verma, Sunita Gupta, R. Saxena, P. Kaur, Rachana R, S. Srivastava and V. Gupta, “Allosteric inhibition and kinetic characterization of Klebsiella pneumoniae CysE: An emerging drug target”. International Journal of Biological macromolecules. 15;151:1240-1249; 2020DOI: 10.1016/j.ijbiomac.2019.10.170 [Impact factor: 8.025 Indexed in Scopus]
• R. Saxena and S. Srivastava,” An insight into impedimetric immunosensor and its electrical equivalent circuit” Sensors & Actuators: B. Chemical vol. 297 pp 126780 (2019) [Impact factor: 9.221, Indexed in Scopus]
• R. Sharma, R. Raghav, P. Kumari, P Rishi, S Sharma, S. Srivastava and I. Verma “Exploiting chitosan and gold nanoparticles for antimycobacterial activity of in silico identified antimicrobial motif of human neutrophil peptide-1” Scientific Reports, 9:7866, (2019) [Impact factor: 4.6, Indexed in Scopus].
• R. Saxena , O. Y. Alothman , S. Srivastava, “Gold Nanoparticle Based Electrochemical Immunosensor for Detection of T3 Hormone” Journal of Nanoelectronics and Optoelectronics (Accepted) (2019) [Impact factor: 1.069, Indexed in Scopus]   
• Rani, D., Saxena, R., Nayak, B., Srivastava, S. Cloning and expression of truncated ORF2 as a vaccine candidate against Hepatitis E Virus, 3Biotech vol 8 pp 414-418, (2018)  [Impact factor: 2.8, Indexed in Scopus]
• Sharma, S. Zapatero-Rodríguez, J.  Saxena, R., Kennedy, R O’ and Srivastava, S. Ultrasensitive direct impedimetric immunosensor for detection of serum HER2 Biosensors and Bioelectronics vol 106, pp 78-85, 2018. [Impact factor: 12.6, Indexed in Scopus]
• Saxena R. and Srivastava S., “Nanoparticles Empowered Microelectrode for Fast and Sensitive Detection of Thyroid Stimulating Hormone” Sensor Letters vol 15, pp 375-379, (2017) [Indexed in SCOPUS, Impact factor: 0.56]
• Sharma, S. Raghav, R.  Kennedy, R.O.  and  Srivastava, S. “Advances in Ovarian Cancer Diagnosis: A Journey from Immunoassays to Immunosensors”  Enzyme and Microbial Technology vol 89, pp 15–30, (2016). [Impact factor: 3.705, Indexed in Scopus]
• Raghav, R.  and  Srivastava,  S.  " Immobilization Strategy for Enhancing Sensitivity of Immunosensors: L-Asparagine-AuNPs as a promising alternative of EDC-NHS activated citrate-AuNPs for Antibody immobilization" Biosensors and Bioelectronics vol 78, pp 396-403, 2016. [Impact factor: 12.6, Indexed in Scopus]
• Raghav R. and Srivastava S., “Copper(II) Oxide Nanoflakes Based Impedimetric Immunosensor for Label Free Determination of Cancer Antigen-125” Sensor Letters vol 14, pp 97-101, (2016) [Indexed in SCOPUS, Impact factor: 0.56]
• Raghav, R.  and  Srivastava, S. "Core-shell Gold-Silver nanoparticles based impedimetric immunosensor for cancer antigen CA125" Sensors and Actuators :B Chemical, vol 220, pp557-564, 2015. [ Impact factor: 9.221, Indexed in SCOPUS]
• Raghav, R.  and Srivastava, S."Gold Nanoparticles Based Colorimetric Detection of Cobalt (II) Ions" Sensor Letters vol 13, pp 254-258, 2015[Indexed in SCOPUS, Impact factor: 0.56]
• Bhatnagar, Y.  Singh, G. B. Mathur, A. Srivastava,  S., Gupta, S. Gupta, N.  ”Biodegradation of carbazole by Pseudomonas sp. GBS.5 immobilized in polyvinyl alcohol beads” Biochem Tech vol 6, no. 3, pp 1003-1007 (2015)
• Raghav, R. and Srivastava, S. “Direct ELISA-based Reagentless Amperometric Immunosensor for Cancer Antigen 125”NanotrendsVol 16, no. 2, 1-6, 2014
• Sharma, S.  and Srivastava, S.  “Gold microwires based amperometric biosensor exploiting microbial architecture” Biosensors and Bioelectronics vol 50, no. 12, pp 174-179, 2013. [Impact factor: 12.6, Indexed in Scopus]
• Shrivastav, A. and Srivastava, S. “Human Sweet Taste Receptor : Complete Structure Prediction and Evaluation”Int. J of Chemical and Analytical sciences,vol 4, no. 1, pp. 24-32, 2013. [Impact factor 0.47]
• Shrivastav, A.  and Srivastava,  S.  “Interaction of Sweet Proteins with Human Sweet Taste Receptor” Research and Reviews : J Pharmaceutical Science, vol 4, no. 1, pp. 1-10, 2013.
• Mehndiratta, P. Jain, A., Srivastava, S. Gupta, N. “Environment Pollution and Nanotechnology” Environment and Pollution, vol 2, no. 2, pp. 49-58, 2013.
• Sharma, S.; Gupta, N. and Srivastava, S. “Modulating Electron Transfer Properties of Gold Nanoparticles for Efficient Biosensing” Biosensors and Bioelectronics vol 37, no. 1, pp. 30 – 37, 2012. [Impact factor: 12.6, Indexed in Scopus]
• Sharma, S.; Goswami, N.; Gupta, N.  and Srivastava, S. “Amino Coated Gold Nanorods Based Amperometric Glucose Detection” International Journal of Advancements in Technology, vol. 3, no. 3, pp. 195-202, 2012.
• Sharma S.  and  Srivastava, S. "Synthesis of Branched Gold Nanostructures with Improved Biocompatibility” Nanotrends  vol 13, no. 1, pp. 40-47, 2012.
• Shrivastav, A.  Gupta, N.  and  Srivastava, S.  “Is AH-B-X Glucophore Sufficient Condition for Sweetness” World Journal of Science and Technology, vol 1, no. 10, pp. 21-29, 2011.
• Singh, G.B.  Gupta, S.Srivastava, S.  and Gupta, N. “Biodegradation of Carbazole by Newly Isolated Acinetobacter spp.,” Bulltein of Environmental Contamination and Toxicology, vol 87, no. 5, pp. 522 – 526, 2011. [Impact factor: 2.65, Indexed in SCOPUS]
• Singh, G.B. Srivastava, A. Saigal, A. Aggarwal, S. Bisht, S. Gupta, S. Srivastava, S. and Gupta, N.  “Biodegradation of carbazole and dibenzothiophene by bacteria isolated from petroleum contaminated sites,” Bioremediation Journal, vol 15, pp. 185-195, 2011 [[Impact factor:2.14, Indexed in SCOPUS]
• Singh, G.B., Gupta, S., Srivastava, S., Gupta, N.  “Evaluation of carbazole degradation by Enterobacter sp. isolated from hydrocarbon contaminated soil,” Recent Research in Science & Technology, vol. 3, no.11, pp. 44 -48, 2011.
• Shrivastav A. and Srivastava S. “Medicinal plants used worldwide for treating diabetes” Jour. Trop. For., vol 26, No. 1, pp 14, 2010.
• Srivastava, S. and Das, S.P., “Transport Coefficients at Metastable Densities from models of Generalized Hydrodynamics” J. Chem. Phys., vol. 116, pp 2529, 2002. [Impact factor:3.4, Indexed in SCOPUS]
• Srivastava, S., Harbola, U., and Das, S.P. “Anamolous Stretching Behavior in a simple Glass forming Liquid” Phys. Rev. E, vol 65, pp 051506, 2002. [Impact factor:2.707, Indexed in Scopus]
• Kaur, C., Srivastava, S. and Das, S.P., “Dynamics of a Metastable Liquid: Comparison of Results from Two Different Approaches”  Phys. Lett. A, vol. 300, No. 2-3, pp 291, 2002. [Impact factor:2.701, Indexed in SCOPUS]
• Srivastava, S. and Das, S.P., “Metastable state dynamics and power law relaxation in a supercooled liquid”. Phys. Rev. E, vol. 63, pp 011505, 2001.[ Impact factor:2.707, Indexed SCOPUS]
• Srivastava, S. and Das, S.P., “Fragility and Boson Peak formation in a supercooled liquid” Phys. Letters A, vol. 286, No. 1, pp 76, 2001. [Impact factor:2.701, Indexed in SCOPUS]
• Srivastava, S. and Das, S.P., “Temperature Dependence of Secondary Relaxation in a Supercooled Liquid” Int. Journal of Mod. Phys. B, vol.15, pp 4199, 2001. [Impact factor:1.219, Indexed in SCOPUS,]
• Das, S.P., and  Srivastava, S., “A Schematic model of glassy relaxation through dynamic Coupling with the defect motions”, Phys. Letters A, vol. 266, pp. 58, 2000. [Impact factor:2.701, Indexed in SCOPUS]

 

BOOK CHAPTER

• Sudha Srivastava, Kushagr Punyani and Shuchi Arora, Chapter 3 : “The Noxious Nanoparticles” in Free Radicals in Human Health & Diseases Rani, V and Yadav, U. C. (Eds.), Springer Publications, pp 31-41, 2015
• Advances in Biotechnology and Life Sciences. Editor: Prof PammiGauba, Co-editor: Prof Sudha Srivastava, Dr Shalini Mani. Publisher: Vidya Kutir Publications, New Delhi. 2020. ISBN:978-81-948426-2-0. 
• Srivastava, S., Sharma, N., Singh, M. (2023). Tissue Oxygenation and pH-Responsive Fluorescent Nanosensors in Tumor Diagnosis. In: Chawla, S., Singh, S., Husen, A. (eds) Smart Nanomaterials Targeting Pathological Hypoxia. Smart Nanomaterials Technology. Springer, Singapore. https://doi.org/10.1007/978-981-99-1718-1_10
• Singh, M., Rajput, R., Agarwal, V., Jindal, D., Pancham, P., Srivastava, S. (2023). Nanotechnology-Based Approaches to Relieve Tumour Microenvironment Hypoxia via Enhanced Oxygen Delivery. In: Chawla, S., Singh, S., Husen, A. (eds) Smart Nanomaterials Targeting Pathological Hypoxia. Smart Nanomaterials Technology. Springer, Singapore. https://doi.org/10.1007/978-9

GENBANK SUBMISSIONS

G.B. Singh, S. Srivastava, S. Gupta and N. Gupta. Pseudomonas sp. enrichment culture clone GBS.5 16S ribosomal RNA gene, partial sequence GenBank Accession No. X193073,2012

• G.B. Singh, S. Gupta, S. Srivastava and N. Gupta. Pseudomonas sp. GBS.5 carbazole terminal oxygenase component (carAa) gene, partial cds GenBank Accession No. JX885589, 2012
• G.B. Singh, S. Gupta, S. Srivastava and N.Gupta. Pseudomonas sp. GBS.5 2-aminobiphenyl-2.3.-diol 1,2 dioxygenase catalytic subunit (carBb) gene partial cds GenBank Accession No. JX885590,2012
• G.B. Singh, S. Gupta, S. Srivastava and N.Gupta. Pseudomonas sp. GBS.5 meta-cleavage compound hydrolase (carCc) gene complete cds GenBank Accession No. JX885591, 2012.
• G.B. Singh, S. Gupta,S. Srivastava and N.Gupta. Pseudomonas sp. Carbazole ferredoxin component(carAc)gene, partial cds GenBank Accession No. JX885592, 2012.
• G.B. Singh,S. Srivastava, S. Gupta and N. Gupta. Acinetobacter sp. enrichment culture clone Alp6 16S ribosomal RNA gene, partial sequence GenBank Accession No. JF828047, 2011.
• G.B. Singh,S. Srivastava, S. Gupta and N.Gupta. Acinetobacter sp. enrichment culture clone Alp7 16S ribosomal RNA gene, partial sequence GenBank Accession No. JF828048, 2011.

 

INTERNATIONAL CONFERENCES

• Co-ordinator: International Conference on Advances in Biosciences and Biotechnology ICABB 2020, 30 Jan- 1 Feb 2020.
• Saxena R. and Srivastava S., “Non-invasive toluene sensor for early diagnosis of lung cancer” AIP Conf. Proc. vol. 1724, pp 020079-1 - 020079-4, 2016. .[Indexed in Scopus]
• Raghav R., Aggarwal P. and Srivastava S. “Tailoring oxides of copper-Cu2O and CuO nanoparticles and evaluation of organic dyes degradation” AIP Conf. Proc. vol. 1724, pp 020078-1 - 020078-5, 2016. [Indexed in Scopus]
• A. Jain, P. Mehndiratta, S. Sharma, G.B. Singh,S. Srivastava and N. Gupta, “Carbazole degradation by nanoparticles aided immobilized bacterial cells “ International conference on Microbial Biotechnology for Sustainable Development. “Nov. 3 - 6, pp 354, Chandigarh, 2011
• Sharma, S., Shrivastav A., Gupta N. and Srivastava, S. “Amperometric biosensor: increased sensitivity using enzyme nanoparticles” Proceedings of international conference on nanobiotechniology and biosensors, Hong Kong, China, Dec 28-30, pp 24-27, 2010.
• Srivastava, S. and Choudhary, P. “Designing safe sweeteners: a photochemical study of sweet molecules/proteins” Proceedings of international conference of photoradiation chemistry, pp 45-46, 2007.
• Srivastava, S.and Das, S.P., “Dynamic Response in a supercooled Liquid” in Solid State Physics vol. 44, S. L. Chaplot, P. S. R. Krishna and T. Sakuntala, Ed. Narosa Publishing, 2002, pp 575.
• Das, S.P.,and Srivastava, S. “Role of vibrational modes in structural relaxation in a supercooled liquid,” AIP Conf. Proc.,vol 469, pp 416-432, 1999.

CONFERENCES/WORKSHOP ORGANIZED

• Co-ordinator : One day IPR Awareness workshop organized by JIIT Noida on Aug. 23,2014.
• Co-ordinator : One Day Patent Search workshop organized by JIIT Noida on Jan. 8, 2015.
• Co-ordinator : FDP on Nanomaterials and Its Applications organized by dept. of Biotechnology, JIIT Noida, July 13 – 18, 2015.
• Co-ordinator : One day Workshop on Intellectual Property & Innovation Management in University, organized by JIIT Noida on Mar. 8, 2016.
• Conducted workshop on Biosensors (lectures and practical sessions) as sole resource person at Summer School, JNU 28-29 June 2018       

PH.D STUDENTS (COMPLETED): (5)

• Shikha Sharma (2012) Topic: Development of a nanoparticle based glucose biosensor.
• Aditi Shrivastav (2013) Topic: Investigating determinants of sweetness in sweet molecules.
• Ragini Raghav (2016) Topic: Development of nanoparticle based immunosensor for cancer antigen CA125.
• Rahul Saxena (2020) Topic Fabrication of nanotechnology based Point-of-Care Device for Detection of Thyroid Disorder
• Dibya Rani (2023) Nanomaterials Based Vaccine Development Against Hepatitis E Virus

 

PH.D STUDENTS (ONGOING): (3)