Dr. Reetika Debroy

BIOGRAPHY

Dr. Reetika Debroy joined the Department of Biotechnology, Jaypee Institute of Information Technology as an Assistant Professor in August, 2024. Dr. Reetika received her Ph.D. degree from Vellore Institute of Technology, Vellore, India, in October 2023. She was awarded with the Senior Research Fellowship sponsored by the Indian Council of Medical Research, Govt. of India (2022). She did her M.Sc. in Applied Microbiology from Vellore Institute of Technology, Vellore, India, in 2019; and B.Sc. in Zoology from Gurucharan College (Affiliated to Assam University), Silchar, in 2017. She has research experience on antimicrobial resistance with specialization in structural bioinformatics, network biology and genomics.

RESEARCH HIGHLIGHTS

Her research interest emphasizes on identification and validation of therapeutic drug targets in opportunistic pathogens using integrated systems biology and structural bioinformatics methods. She performed her doctoral research on formulating targeted-therapy strategies against antimicrobial resistance in nosocomial pathogens through genomic screenings, analysing high-throughput data, protein-protein interaction network studies, in- silico drug target optimizations, dynamics simulation studies and ligand optimization methods. She has expertise in several sub-domains of microbial informatics including whole genome analysis, genome annotation, phylogenetics, variant calling, transcriptomic data analysis, differential gene expression studies, interactomics (protein-protein interaction, gene-gene interaction, host-pathogen protein-protein interaction), functional enrichment analysis, gene ontology analysis, protein/gene clustering analysis, network topology analysis (centrality, degree, shortest path length), protein modelling, tertiary protein structure optimizations and validations, mutational analysis, druggability predictions, pharmacokinetic screening of ligands, ligand structure optimizations, virtual screening, molecular docking, molecular dynamics simulations and post-dynamics simulation studies, Monte Carlo simulations and principal component analysis.

PUBLICATIONS

• Debroy, R., & Ramaiah, S. (2023). Consolidated knowledge-guided computational pipeline for therapeutic intervention against bacterial biofilms-a review. Biofouling, 1-20. https://doi.org/10.1080/08927014.2023.2294763
• Naha, A., Debroy, R., Sharma, D., Shah, M. P., & Nath, S. (2023). Microbial fuel cell: A state-of-the-art and revolutionizing technology for efficient energy recovery. Cleaner and Circular Bioeconomy, 5, 100050. https://doi.org/10.1016/j.clcb.2023.100050.
• Debroy, R., & Ramaiah, S. (2023). Translational protein RpsE as an alternative target for novel nucleoside analogues to treat MDR Enterobacter cloacae ATCC 13047: network analysis and molecular dynamics study. World Journal of Microbiology and Biotechnology, 39(7), 187. https://doi.org/10.1007/s11274-023-03634-z
• Basu, S., Debroy, R., Kumar, H., Singh, H., Ramaiah, S., & Anbarasu, A. (2023). Bioactive phytocompounds against specific target proteins of Borrelia recurrentis responsible for louse‐borne relapsing fever: Genomics and structural bioinformatics evidence. Medical and Veterinary Entomology, 37(2), 213-218. https://doi.org/10.1111/mve.12623
• Basu, S., Ashok, G., Debroy, R., Ramaiah, S., Livingstone, P., & Anbarasu, A. (2023). Impact of the COVID-19 pandemic on routine vaccine landscape: A global perspective. Human Vaccines & Immunotherapeutics, 2199656. https://doi.org/10.1080/21645515.2023.2199656
• Debroy, R., & Ramaiah, S. (2022). MurC ligase of multi-drug resistant Salmonella Typhi can be inhibited by novel Curcumin derivative: Evidence from molecular docking and dynamics simulations. The International Journal of Biochemistry & Cell Biology, 151, 106279. https://doi.org/10.1016/j.biocel.2022.106279
• Basu, S., Varghese, R., Debroy, R., Ramaiah, S., Veeraraghavan, B., & Anbarasu, A. (2022). Non-steroidal anti-inflammatory drugs ketorolac and etodolac can augment the treatment against pneumococcal meningitis by targeting penicillin-binding proteins. Microbial Pathogenesis, 170, 105694. https://doi.org/10.1016/j.micpath.2022.105694
• Priyamvada, P., Debroy, R., Anbarasu, A., & Ramaiah, S. (2022). A comprehensive review on genomics, systems biology and structural biology approaches for combating antimicrobial resistance in ESKAPE pathogens: computational tools and recent advancements. World Journal of Microbiology and Biotechnology, 38(9), 1-14. https://doi.org/10.1007/s11274-022-03343-z
• Naha, A., Banerjee, S., Debroy, R., Basu, S., Ashok, G., Priyamvada, P., ...& Ramaiah, S.(2022). Network metrics, structural dynamics and density functional theory calculations identified a novel Ursodeoxycholic Acid derivative against therapeutic target Parkin for Parkinson's disease. Computational and Structural Biotechnology Journal, 20, 4271-4287. https://doi.org/10.1016/j.csbj.2022.08.017
• Miryala, S. K., Basu, S., Naha, A., Debroy, R., Ramaiah, S., Anbarasu, A., & Natarajan, S. (2022). Datasets comprising the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of Mycobacterium tuberculosis protein-targets. Data in Brief, 42, 108146. https://doi.org/10.1016/j.dib.2022.108146
• Miryala, S. K., Basu, S., Naha, A., Debroy, R., Ramaiah, S., Anbarasu, A., & Natarajan, S. (2021). Identification of bioactive natural compounds as efficient inhibitors against Mycobacterium tuberculosis protein-targets: A molecular docking and molecular dynamics simulation study. Journal of Molecular Liquids, 117340. https://doi.org/10.1016/j.molliq.2021.117340
• Debroy, R., Miryala, S. K., Naha, A., Anbarasu, A., & Ramaiah, S. (2020). Gene interaction network studies to decipher the multi-drug resistance mechanism in Salmonella enteric serovar Typhi CT18 reveal potential drug targets. Microbial Pathogenesis, 142, 104096. https://doi.org/10.1016/j.micpath.2020.104096
• Naha, A., Miryala, S. K., Debroy, R., Ramaiah, S., & Anbarasu, A. (2020). Elucidating the multi-drug resistance mechanism of Enterococcus faecalis V583: A gene interaction network analysis. Gene, 144704. https://doi.org/10.1016/j.gene.2020.144704

SOCIETY MEMBERSHIPS

• Bioinformatics and Drug Discovery Society (BIDDS) [December 2022 - Present]

HONORS/AWARDS

• Senior Research Fellowship (SRF) awarded by Indian Council of Medical Research, Govt. Of India [May 2022-May 2023]

CONFERENCE PRESENTATIONS

• Presented a poster on “Novel curcumin derivative can inhibit MurC ligase to obstruct peptidoglycan biosynthesis in multi-drug resistant Salmonella Typhi: Evidence from molecular docking and Dynamic simulations” at International Conference on "Contemporary Antimicrobial Research” [Assam University, Silchar, India, 16/11/2023 – 18/11/2023]
• Oral presentation on “Novel curcumin derivative can interfere with MurC ligase-dependent peptidoglycan biosynthesis in multi-drug resistant Salmonella Typhi: Evidence from Molecular Docking and Dynamics Simulations” at International Conference on "Next Generation Microbiologists Challenges and Opportunities 2.0” [DG Vaishnav College, Chennai, India, 02/02/2023 – 03/02/2023]
• Presented a poster on “Novel curcumin derivative can inhibit MurC ligase to obstruct peptidoglycan biosynthesis in multi-drug resistant Salmonella Typhi: Evidence from Molecular Docking and Dynamics Simulations” at International conference cum workshop on - “Recent trends in Structural Bioinformatics and Computer aided Drug design” [Alagappa University, Karaikudi, India, 21/11/2022 – 25/11/2022]
• Presented a poster on “Understanding the role of FYN gene towards the development of Alzheimer’s disease – An in-silico approach” at 5th IITM - Tokyo tech joint symposium on "Current trends in Bioinformatics: Big data analysis, machine learning and drug design" [Indian Institute Of Technology, Madras, India, 06/03/2020 – 07/03/2020]
• Presented a poster on “Gene interaction network studies to understand the multi-drug resistance in bacterial species of Enterobacteriaceae family” at International conference on “Bacteriophage research and Antimicrobial resistance” [Vellore Institute of Technology, Vellore, India, 12/12/2019 – 13/12/2019]

CONFERENCES ATTENDED

• International symposium on “Proteomics Research at VIT – Challenges and Opportunities” [Vellore Institute of Technology, Vellore, India, 21/03/2022 – 21/03/2022]
• International conference on “Molecular typing and genome-wide analysis of clinical pathogens on AMR: An update” [Christian Medical College (CMC), Vellore, India, 03/03/2021 – 05/03/2021]
• International conference on “Advanced bioinformatics analysis to mine AMR and virulence information from high throughout sequencing data” [Christian Medical College (CMC), Vellore, India, 12/08/2021 – 14/08/2021]
• International Symposium on Bioinformatics (InSyB) jointly organized by Sri Venkateswara College, University of Delhi; Department of Biophysics, University of Delhi; Bennett University (The Times Group) and supported by Asia Pacific Bioinformatics Network (APBioNET) on Nov 29,2024